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Article

B cell signalling pathways—New targets for precision medicine in chronic lymphocytic leukaemia

8 Jul 2020

Abstract excerpt

The B cell receptor (BCR) is a master regulator of B cells, controlling cellular processes such as proliferation, migration and survival. Cell signalling downstream of the BCR is aberrantly activated in the B cell malignancy chronic lymphocytic leukaemia (CLL), supporting the pathophysiology of the disease. This insight has led to development and approval of small molecule inhibitors that target components of the...

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PMID: 32640099
DOI: 10.1111/sji.12931

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