Article

Generation of Eμ-PKCβII transgenic mice for the study of chronic lymphocytic leukaemia (CLL)

2013-01-01

Abstract excerpt

The malignant cells of chronic lymphocytic leukemia (CLL) over-express PKCβII, a feature pathogenically important because the TCL1 mouse model of CLL fails to develop disease when PKCβ expression is disrupted. The purpose of this project was to generate transgenic mice in which PKCβII is over-expressed only in B cells. The central hypothesis of this thesis was that over-expression of PKCII in developing B cells w...

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Literature Corpus work: 092f0516-f93a-5414-b9f8-2b91a551ecee
DOI: 10.17638/00015335

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