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Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer

28 Sept 2022

Abstract excerpt

Aberrant expression of protein kinase C (PKC) isozymes is a hallmark of cancer. The different members of the PKC family control cellular events associated with cancer development and progression. Whereas the classical/conventional PKCα isozyme has been linked to tumor suppression in most cancer types, here we demonstrate that this kinase is required for the mitogenic activity of aggressive human prostate cancer...

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Cytokine Signaling Pathways and Interactions
Melanoma and MAPK Pathways
Protein Kinase Regulation and GTPase Signaling

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36818489
DOI: 10.1158/2767-9764.crc-22-0170

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