Article

Mesenchymal stem cells derived exosomes ameliorate D-galN/LPS induced acute liver injury via PTEN-mediated macrophage polarization

2023-11-03

Abstract excerpt

<h4>Background: </h4> It is widely acknowledged that Mesenchymal Stem Cells (MSCs) exert their effects through paracrine mechanisms by releasing bioactive components, such as exosomes, while previous studies have confirmed the critical role of macrophage polarization in acute liver injury, the impact of exosome-mediated liver repair on macrophage polarization requires further clarification. <h4>Methods: </h4> Huma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b79050bd-439b-5f45-af3e-40ad2404636a
DOI: 10.21203/rs.3.rs-3485571/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal stem cells derived exosomes ameliorate D-galN/LPS induced acute liver injury via PTEN-mediated macrophage polarizationDOI 10.21203/rs.3.rs-3485571/v1Read

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in ratsSemantic proximity Read

Long-term expanded hepatic progenitor cells ameliorate D-GalN/LPS-induced acute liver failure through repolarizing M1 macrophage to M2-Like phenotype via activation of the IL-10/JAK2/STAT3 signaling pathway.Semantic proximity Read

Exosomes Derived from liver failure patients' plasma stimulated Mesenchymal Stem Cells alleviate acute liver failureSemantic proximity Read

Ischemia and reperfusion-injured liver-derived exosomes elicit acute lung injury through miR-122-5p regulated alveolar macrophage polarizationSemantic proximity Read

Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cellsSemantic proximity Read

Human umbilical cord mesenchymal stem cells derived Exosomes attenuate injury of myocardial infarction by miR-24-3p-promoted M2 macrophage polarizationSemantic proximity Read

Mesenchymal Stem Cells Induce a Fibrolytic Phenotype By Regulating mmu-miR-6769b-5p Expression in Macrophages.Semantic proximity Read

3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathwaySemantic proximity Read

Exosomal miR-21 secreted by IL-1β-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis.Semantic proximity Read

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failureSemantic proximity Read

MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosisSemantic proximity Read

Exosomal miRNAs-mediated macrophage polarization and its potential clinical application.Semantic proximity Read