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Mesenchymal Stem Cells Induce a Fibrolytic Phenotype By Regulating mmu-miR-6769b-5p Expression in Macrophages.

Stem cells and development - 15 Nov 2020

Nishi Maiko, Matsumoto Toshihiko, Fujisawa Koichi, Suehiro Yutaka, Takami Taro, Yamamoto Naoki, Yamasaki Takahiro, Sakaida Isao

Abstract excerpt

Liver transplantation is the only radical treatment for decompensated cirrhosis, but its use is limited owing to a shortage of donors; hence, there is an urgent need for new treatments. Previously, we developed a liver-regeneration therapy using autologous bone marrow-derived mesenchymal stem cells (BMSCs), which is under clinical investigation. Cell-cell interactions between BMSCs and macrophages (Mφs)...

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PMID: 32962510
DOI: 10.1089/scd.2020.0123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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