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Article

Exosomal miR-21 secreted by IL-1β-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis.

Life sciences - 1 Jan 2021

Yao Mengying, Cui Bing, Zhang Weihong, Ma Wentao, Zhao Gaofeng, Xing Lihua

Abstract excerpt

Sepsis occurs due to a damaging host response to infection and is the chief cause of death in most intensive care units. Mesenchymal stem cells (MSCs) exhibit immunomodulatory properties and can modulate key cells of the innate and adaptive immune systems through various effector mechanisms, such as exosomes. Exosomes and their microRNA (miRNA or miR) cargo including miR-21 can initiate profound phenotypic...

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Identifiers

PMID: 33115604
DOI: 10.1016/j.lfs.2020.118658

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