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Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells

5 Feb 2025

Abstract excerpt

BACKGROUND: The progression of liver fibrosis involves complex interactions between hepatic stellate cells (HSCs) and multiple immune cells in the liver, including macrophages. However, the mechanism of exosomes in the crosstalk between liver macrophages and HSCs remains unclear. METHOD: Exosomes were extracted from primary mouse macrophages and cultured with HSCs, and the differential expression of microRNAs was...

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PMID: 39910671
DOI: 10.1186/s40246-025-00722-z

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