Article
Long-term expanded hepatic progenitor cells ameliorate D-GalN/LPS-induced acute liver failure through repolarizing M1 macrophage to M2-Like phenotype via activation of the IL-10/JAK2/STAT3 signaling pathway.
International immunopharmacology - 5 Dec 2024
Li Hongsheng, Chen Chen, Huang Weijian, Shi Lei, Zhang Qin, Zhou Li, Huang Hai, Zhou Shen'ao
Abstract excerpt
Acute liver failure (ALF) is a devastating liver disease characterized by the rapid deterioration of hepatocytes, which causes a series of clinical complications, including hepatic dysfunction, coagulopathy, encephalopathy, and multiorgan failure. Cell-based therapy is a promising alternative as it can bridge patients until their livers regenerate, releasing immunomodulatory molecules to suppress inflammation....
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