Article

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in rats

2022-11-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Decompensated liver cirrhosis (DLC), a terminal-stage complication of liver disease, is a major cause of morbidity and mortality in patients with hepatopathie. Human umbilical cord mesenchymal stem cell (hUCMSCs) therapy has emerged as a treatment novel alternative for the treatment of DLC. However, optimized therapy protocols and the associated mechanisms are n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 847eb0a7-7766-53ba-9618-025c516ac1f8
DOI: 10.21203/rs.3.rs-1999570/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in ratsDOI 10.21203/rs.3.rs-1999570/v1Read

Ambiguous Pathogenic Roles of Macrophages in Alcohol-Associated Liver DiseasesSemantic proximity Read

Long-term expanded hepatic progenitor cells ameliorate D-GalN/LPS-induced acute liver failure through repolarizing M1 macrophage to M2-Like phenotype via activation of the IL-10/JAK2/STAT3 signaling pathway.Semantic proximity Read

Macrophage Phenotype in Liver Injury and RepairSemantic proximity Read

Mesenchymal stem cells derived exosomes ameliorate D-galN/LPS induced acute liver injury via PTEN-mediated macrophage polarizationSemantic proximity Read

Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 PathwaySemantic proximity Read

Overexpression of HNF4α enhances umbilical cord mesenchymal stem cell function to treat acute liver failure in mice through macrophage polarizationSemantic proximity Read

Macrophage Polarization and Its Role in Liver Disease.Semantic proximity Read

Intrahepatic Macrophage Reprogramming Associated with Lipid Metabolism in Hepatitis B Virus-Related Acute-on-Chronic Liver FailureSemantic proximity Read

Understanding Macrophage Complexity in Metabolic Dysfunction-associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial DynamicsSemantic proximity Read

Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial DynamicsSemantic proximity Read

Myeloid cell path to malignancy: insights into liver cancerSemantic proximity Read

MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosisSemantic proximity Read