Article
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2020
Tischkowitz Marc, Huang Sidong, Banerjee Susana, Hague Jennifer, Hendricks William P D, Huntsman David G, Lang Jessica D, Orlando Krystal A, Oza Amit M, Pautier Patricia, Ray-Coquard Isabelle, Trent Jeffrey M, Witcher Michael, Witkowski Leora, McCluggage W Glenn, Levine Douglas A, Foulkes William D, Weissman Bernard E
Abstract excerpt
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often germline pathogenic variants in SMARCA4, which encodes for the SMARCA4 protein (BRG1), a subunit of the SWI/SNF chromatin remodeling complex. Approximately 20% of human cancers possess pathogenic variants in at least one SWI/SNF subunit....
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