Article
Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.
Oncotarget - 12 Jan 2016
Fahiminiya Somayyeh, Witkowski Leora, Nadaf Javad, Carrot-Zhang Jian, Goudie Catherine, Hasselblatt Martin, Johann Pascal, Kool Marcel, Lee Ryan S, Gayden Tenzin, Roberts Charles W M, Biegel Jaclyn A, Jabado Nada, Majewski Jacek, Foulkes William D
Abstract excerpt
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian malignancy diagnosed in women under age 40. We and others recently determined that germline and/or somatic deleterious mutations in SMARCA4 characterize SCCOHT. Alterations in this gene, or the related SWI/SNF chromatin remodeling gene SMARCB1, have been previously reported in atypical teratoid/rhabdoid...
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