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A Cholesterol Biosynthesis Inhibitor Blocks <i>Staphylococcus aureus</i> Virulence

14 Feb 2008

Abstract excerpt

Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus, staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined the...

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PMID: 18276850
DOI: 10.1126/science.1153018

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