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Article

Mechanistic insights into oxidosqualene cyclizations through homology modeling.

Journal of computational chemistry - 30 Apr 2003

Schulz-Gasch Tanja, Stahl Martin

Abstract excerpt

2,3-Oxidosqualene cyclases (OSC) are key enzymes in sterol biosynthesis. They catalyze the stereoselective cyclization and skeletal rearrangement of (3S)-2,3-oxidosqualene to lanosterol in mammals and fungi and to cycloartenol in algae and higher plants. Sequence information and proposed mechanis...

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PMID: 12666166
DOI: 10.1002/jcc.10147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12666166-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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