Article

The ER protein translocation channel subunit Sbh1 controls virulence of <i>Cryptococcus neoformans</i>

2022-06-01

Abstract excerpt

The fungal pathogen Cryptococcus neoformans is distinguished by a cell wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins with polypeptide translocation across the endoplasmic reticulum (ER) membrane through a highly conserved channel formed by three proteins: Sec61, Sbh1, and Sss1. Sbh1, the most...

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Literature Corpus work: 069923f4-d6b4-57dc-acf7-a354b1a037f3
DOI: 10.1101/2022.06.01.494298

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