Article

Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach

2022-03-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Variation in genes involved in ethanol metabolism has been shown to influence risk for alcohol dependence (AD) including protective loss of function alleles in ethanol metabolizing genes. We therefore hypothesized that people with severe AD would exhibit different patterns of rare functional variation in genes with strong prior evidence for influencing ethanol metabolism and...

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Literature Corpus work: b7783dd3-cc4c-554a-86e3-943b2dd13ab9
DOI: 10.1101/2022.03.16.484608

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