Article
Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach.
PloS one - 1 Jan 2023
Gentry Amanda Elswick, Alexander Jeffry C, Ahangari Mohammad, Peterson Roseann E, Miles Michael F, Bettinger Jill C, Davies Andrew G, Groteweil Mike, Bacanu Silviu A, Kendler Kenneth S, Riley Brien P, Webb Bradley T
Abstract excerpt
BACKGROUND: Variation in genes involved in ethanol metabolism has been shown to influence risk for alcohol dependence (AD) including protective loss of function alleles in ethanol metabolizing genes. We therefore hypothesized that people with severe AD would exhibit different patterns of rare functional variation in genes with strong prior evidence for influencing ethanol metabolism and response when compared to...
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