Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.

Oncogene - 1 Jan 2021

He Di, Wang Di, Lu Ping, Yang Nan, Xue Zhigang, Zhu Xianmin, Zhang Peng, Fan Guoping

Abstract excerpt

Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population. However, the inter-patient and intra-tumor heterogeneity has not been addressed at single-cell resolution. Here we performed single-cell RNA sequencing (scRNA-seq) of total 125,674 cells from seven stage-I/II LUAD samples harboring EGFR mutations and five tumor-adjacent lung tissues. We identified diverse cell types within the tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Lymphocytes, Tumor-Infiltrating

Share to Myeloid Cells

Share to Sequence Analysis, RNA

Share to Single-Cell Analysis

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 33144684
DOI: 10.1038/s41388-020-01528-0
PMCID: PMC7808940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.PMID 33144684Read ↗

Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinomaSemantic proximity Read ↗

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.Semantic proximity Read ↗

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity Read ↗

The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencingSemantic proximity Read ↗

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity Read ↗

Characterizing Tumor Microenvironment and Risk Genes in Lung Adenocarcinoma through scRNA-seq and Bulk RNA-seq DataSemantic proximity Read ↗

Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancerSemantic proximity Read ↗

Single-cell RNA sequencing reveals potential therapeutic targets in the tumor microenvironment of lung squamous cell carcinomaSemantic proximity Read ↗

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma.Semantic proximity Read ↗

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencingSemantic proximity Read ↗

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinomaSemantic proximity Read ↗

Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.