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Article

The role of Alzheimer's disease risk genes in endolysosomal pathways.

Neurobiology of disease - 1 Jan 2022

Szabo Marcell P, Mishra Swati, Knupp Allison, Young Jessica E

Abstract excerpt

There is ample pathological and biological evidence for endo-lysosomal dysfunction in Alzheimer's disease (AD) and emerging genetic studies repeatedly implicate endo-lysosomal genes as associated with increased AD risk. The endo-lysosomal network (ELN) is essential for all cell types of the central nervous system (CNS), yet each unique cell type utilizes cellular trafficking differently (see Fig. 1). Challenges...

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Identifiers

PMID: 34871734
DOI: 10.1016/j.nbd.2021.105576
PMCID: PMC9071255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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