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Article

Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease.

Brain : a journal of neurology - 1 Sept 2018

Gao Song, Casey Aaron E, Sargeant Tim J, Mäkinen Ville-Petteri

Abstract excerpt

Late-onset Alzheimer's disease is the most common dementia type, yet no treatment exists to stop the neurodegeneration. Evidence from monogenic lysosomal diseases, neuronal pathology and experimental models suggest that autophagic and endolysosomal dysfunction may contribute to neurodegeneration by disrupting the degradation of potentially neurotoxic molecules such as amyloid-β and tau. However, it is uncertain...

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Identifiers

PMID: 30124770
DOI: 10.1093/brain/awy197

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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