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Article

Integrated pathway analysis identifies prognostically relevant subtypes of glioblastoma characterized by abnormalities in multi-omics.

Clinical and translational medicine - 1 Dec 2025

Zhang Pei, Liu Dan, Yu Tonghui, Zhang Yanlin, Zhong Lu, Ouyang Xiao, Xia Qin, Dong Lei

Abstract excerpt

BACKGROUND: Gene expression-based molecular subtypes in glioblastoma from The Cancer Genome Atlas Network (TCGA-GBM) unraveled the pathological origins by identifying tumour cell driver genes. However, the causal inference between molecular subtype origins and their therapeutic efficacy remains obscure. METHODS: We integrated TCGA-GBM multi-omics (DNA, mRNA, and protein profiles) using correlation analysis to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41292185
DOI: 10.1002/ctm2.70517
PMCID: PMC12647366

Genes

TP53
IDH1
EGFR
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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