Article

Single-cell transcriptional diversity is a hallmark of developmental potential

2019-05-30

Abstract excerpt

Single-cell RNA-sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation without prior knowledge has remained challenging. Here we describe a simple yet robust determinant of developmental potential—the number of detectably expressed genes per cell— and leverage this measure of transcriptional diversit...

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Identifiers and source

Literature Corpus work: a34f2558-a818-53c6-a8c5-919de0a5111c
DOI: 10.1101/649848

Open publication

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