Article

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

2021-04-08

Abstract excerpt

Post-translational modification of histone H4 by the small ubiquitin-like modifier (SUMO) protein was associated with gene repression. However, this could not be proven due to the challenge of site-specifically sumoylating H4 in cells. Biochemical crosstalk between SUMO and other histone modifications, such as H4 acetylation and H3 methylation, that are associated with active genes also remains unclear. We address...

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Literature Corpus work: b7351bdb-9b8e-5547-8908-0e12305a6891
DOI: 10.1101/2021.04.08.439039

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