Article
A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer's disease
2018-04-26
Abstract excerpt
Growing recognition of the pivotal role microglia play in neurodegenerative and neuroinflammatory disorders has accentuated the need to better characterize their function in health and disease. Studies in mouse, have applied transcriptome-wide profiling of microglia to reveal key features of microglial ontogeny, functional profile and phenotypic diversity. Whilst similar in many ways, human microglia exhibit clear...
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Identifiers and source
- Literature Corpus work
- 3b4450a7-3e4c-5ffc-861e-e00dc50b815d
- DOI
- 10.1101/308908