Article

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome

2017-12-13

Abstract excerpt

Endogenous retroviruses (ERVs) are ancient viral elements that have accumulated in the genome through retrotransposition events. Although they have lost their ability to transpose, many of the long terminal repeats (LTRs) that originally flanked full-length ERVs maintain the ability to regulate transcription. While these elements are typically repressed in somatic cells, when this repression is lost, they can func...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 973e9949-178f-5b13-8f27-cbd26cf05b95
DOI: 10.1101/233163

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptomeDOI 10.1101/233163Read

EBV Latency Programs: Molecular and Epigenetic Regulation and Its Role in Disease PathogenesisSemantic proximity Read

The Impact of Epstein-Barr Virus Infection on Epigenetic Regulation of Host Cell Gene Expression in Epithelial and Lymphocytic MalignanciesSemantic proximity Read

The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversionSemantic proximity Read

RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B LymphocytesSemantic proximity Read

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivationSemantic proximity Read

Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivationSemantic proximity Read

Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genomeSemantic proximity Read

Epstein-Barr virus reprograms human B-lymphocytes immediately in the pre-latent phase of infectionSemantic proximity Read

Epigenetic Mechanisms in Latent Epstein-Barr Virus Infection and Associated CancersSemantic proximity Read

Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.Semantic proximity Read

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growthSemantic proximity Read

Molecular Basis of Epstein–Barr Virus Latency Establishment and Lytic ReactivationSemantic proximity Read