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Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma

19 Dec 2013

Abstract excerpt

Transformation of follicular lymphoma (FL) to a more aggressive disease is associated with rapid progression and death. Existing molecular markers for transformation are few and their clinical impact is limited. Here, we report on a whole-genome study of DNA copy numbers and gene expression profiles in serial FL biopsies. We identified 698 genes with high correlation between gene expression and copy number, and...

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PMID: 24357726
DOI: 10.1182/blood-2013-07-512392

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