Article

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

2020-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Current protocols for producing cerebellar neurons from human pluripotent stem cells (hPSCs) are reliant on animal co-culture and mostly exist as monolayers, which have limited capability to recapitulate the complex arrangement of the brain. We developed a method to differentiate hPSCs into cerebellar organoids that display hallmarks of in vivo cerebellar development. Single-cell profiling foll...

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Literature Corpus work: b70c87b1-1a60-57eb-95bb-6189b28d81d8
DOI: 10.1101/2020.07.01.182196

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