Article

Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids

2024-08-15

Abstract excerpt

Faithful genetically engineered in vivo models of medulloblastoma (MB) are currently available only for some molecular subgroups, in keeping with recent studies showing the unique role of human-specific progenitors in the development of G3 and G4 MB subgroups. We generated human cerebellar organoids (CbO) from expanded potential stem cells (EPSC) and characterised their epigenetic and transcriptomic profile compa...

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Literature Corpus work: 6c7e40ab-bee6-5304-877e-6c2c52c2f62d
DOI: 10.1101/2024.08.14.607977

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