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Article

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.

Nature communications - 15 Oct 2022

Lynall Mary-Ellen, Soskic Blagoje, Hayhurst James, Schwartzentruber Jeremy, Levey Daniel F, Pathak Gita A, Polimanti Renato, Gelernter Joel, Stein Murray B, Trynka Gosia, Clatworthy Menna R, Bullmore Ed

Abstract excerpt

Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they are driven by psychiatric risk variants, remains unclear. We test for enrichment of GWAS variants associated with multiple psychiatric disorders (cross-disorder or trans-diagnostic risk), or 5 specific disorders (cis-diagnostic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36243721
DOI: 10.1038/s41467-022-33885-7
PMCID: PMC9569335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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