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Article

Genomics-driven integrative analysis highlights immune-related plasma proteins for psychiatric disorders.

Journal of affective disorders - 1 Feb 2025

Gong Weiming, Guo Ping, Liu Lu, Yan Ran, Liu Shuai, Wang Shukang, Xue Fuzhong, Zhou Xiang, Sun Xiubin, Yuan Zhongshang

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous variants associated with psychiatric disorders. However, it remains largely unknown on how GWAS risk variants contribute to psychiatric disorders. METHODS: Through integrating two largest, publicly available, independent protein quantitative trait loci datasets of plasma protein and nine large-scale GWAS summary statistics of psychiatric...

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PMID: 39491680
DOI: 10.1016/j.jad.2024.10.126

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