Article
Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders.
Human genetics - 1 Jun 2023
Dang Xinglun, Song Meng, Lv Luxian, Yang Yongfeng, Luo Xiong-Jian
Abstract excerpt
Immune dysregulation has been consistently reported in psychiatric disorders, however, the causes and mechanisms underlying immune dysregulation in psychiatric disorders remain largely unclear. Here we conduct a Mendelian randomization study by integrating plasma proteome and GWASs of schizophrenia, bipolar disorder and depression. The primate-specific immune-related protein BTN3A3 showed the most significant...
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