Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.

doi:10.1186/s12888-023-05081-4

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Article

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study.

BMC psychiatry - 15 Aug 2023

Wang Chengdong, Zhu Dongdong, Zhang Dongjun, Zuo Xiaowei, Yao Lei, Liu Teng, Ge Xiaodan, He Chenlu, Zhou Yuan, Shen Ziyuan

Abstract excerpt

BACKGROUND: Complex immune-brain interactions that affect neural development, survival and function might have causal and therapeutic implications for psychiatric illnesses. However, previous studies examining the association between immune inflammation and schizophrenia (SCZ) have yielded inconsistent findings. METHODS: Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the...

Topics

Humans
Schizophrenia
Mendelian Randomization Analysis
Brain
Inflammation
Phenotype
Genome-Wide Association Study

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Identifiers

PMID: 37582716
DOI: 10.1186/s12888-023-05081-4
PMCID: PMC10428653

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