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Article

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

19 Jul 2016

Abstract excerpt

Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics. The aim of this study was to examine the hypothesis that WFS1 deficiency affects neuronal function via mitochondrial abnormalities. We show that down-regulation of WFS1 in neurons leads to dramatic changes...

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PMID: 27434582
DOI: 10.1371/journal.pbio.1002511

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