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Article

Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy

23 Jul 2018

Abstract excerpt

Abstract WD repeat and FYVE domain-containing 3 (WDFY3; also known as Autophagy-Linked FYVE or Alfy) is an identified intellectual disability, developmental delay and autism risk gene. This gene encodes for a scaffolding protein that is expressed in both the developing and adult central nervous system and required for autophagy and aggrephagy with yet unexplored roles in mitophagy. Given that mitochondrial...

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PMID: 30054502
DOI: 10.1038/s41598-018-29421-7

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