Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases

Abstract excerpt

Citrullination, the post-translational modification of arginine residues, is catalyzed by the four catalytically active peptidylarginine deiminase (PAD or PADI) isozymes and alters charge to affect target protein structure and function. PADs were initially characterized in rodent uteri and, since then, have been described in other female tissues including ovaries, breast, and the lactotrope and gonadotrope cells...

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• Cell Adhesion Molecules Research
• Protease and Inhibitor Mechanisms
• Signaling Pathways in Disease