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Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

2024-03-27

Abstract excerpt

Adoptive T cell therapy (ACT) is a promising therapeutic option that enhances the anti-cancer immune response to recognize and eliminate tumor burden. Recently, ACT modalities with autologous tumor-infiltrating lymphocytes (TILs) have shown robust anti-tumor efficacy in solid tumors. However, this therapeutic strategy’s application remains suboptimal in stability and faces critical challenges, primarily due to the...

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Identifiers and source

Literature Corpus work
217de0fb-c724-56da-ae1a-f9c625470984
DOI
10.1101/2024.03.21.586203
Open publication

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