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Article

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

2025-05-06

Abstract excerpt

Macrophages in the tumor microenvironment exert potent anti-tumorigenic activity through phagocytosis. Yet therapeutics that enhance macrophage phagocytosis have not improved outcomes in clinical trials for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). To systematically identify regulators of phagocytosis, we performed genome-scale CRISPR knockout screens in human leukemia cells co-...

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Identifiers and source

Literature Corpus work
b6dbcfd1-12db-550b-9239-53d7801de77c
DOI
10.1101/2025.05.05.652090
Open publication

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Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosisDOI 10.1101/2025.05.05.652090
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