Article

Cancer cell phagocytosis induces an anti-inflammatory gene regulatory program in macrophages

2025-08-22

Abstract excerpt

Macrophages are capable of eliminating cancer cells by phagocytosis, particularly in the presence of monoclonal antibody (mAb) therapies targeting tumor antigens. Paradoxically, tumor-associated macrophages are typically associated with poor patient outcome, and can promote tumor growth by secretion of immunosuppressive cytokines and growth factors. The mechanisms by which these pro-tumor macrophage states arise a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e988717-938d-5a75-9f74-703c1fb975b5
DOI: 10.1101/2025.08.18.670953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cancer cell phagocytosis induces an anti-inflammatory gene regulatory program in macrophagesDOI 10.1101/2025.08.18.670953Read

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.Semantic proximity Read

Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies.Semantic proximity Read

Tissue‐Resident Macrophages in Cancer: Friend or Foe?Semantic proximity Read

Tumor-associated macrophages: functional diversity, clinical significance, and open questions.Semantic proximity Read

Unmasking the Many Faces of Tumor-Associated Neutrophils and Macrophages: Considerations for Targeting Innate Immune Cells in CancerSemantic proximity Read

CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentationSemantic proximity Read

Inhibition of furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities.Semantic proximity Read

Tumour-associated macrophages and cancer.Semantic proximity Read

Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.Semantic proximity Read

Tumor associated macrophages and neutrophils in tumor progressionSemantic proximity Read

Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancerSemantic proximity Read

Macrophage Plasticity: Phenotypic and Functional Profiles Across Pathological Microenvironments.Semantic proximity Read