Back to search

Article

SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels

2025-05-07

Abstract excerpt

<title>Abstract</title> <p>Background Pediatric high-grade gliomas (pHGGs) are heterogeneous, diffuse, and infiltrative tumors with dismal prognosis. Recent molecular characterization of pHGGs has revealed aberrant post-translational histone modifications with elevated histone 3 lysine trimethylation (H3K9) to be implicated in their pathology. Herein, we investigate the biological role of suppressor of variegati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b6d8c62f-23c6-5d39-b40d-c1242d222347
DOI
10.21203/rs.3.rs-6443083/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levelsDOI 10.21203/rs.3.rs-6443083/v1
Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.Semantic proximity
H3K27-Altered Diffuse Midline Glioma of the Brainstem: From Molecular Mechanisms to Targeted Interventions.Semantic proximity
Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefitSemantic proximity
BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.Semantic proximity
Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targetsSemantic proximity
Clinical and Molecular Features of Disseminated Pediatric Low Grade Glioma - A Systematic Review of LiteratureSemantic proximity
H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers.Semantic proximity
A subset of pediatric thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of <i>EGFR</i>Semantic proximity
Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)Semantic proximity
Pediatric diffuse midline glioma: Understanding the mechanisms and assessing the next generation of personalized therapeuticsSemantic proximity
Hemispherical Pediatric High-Grade Glioma: Molecular Basis and Therapeutic OpportunitiesSemantic proximity
Mutations in chromatin machinery and pediatric high-grade glioma.Semantic proximity
Select a neighboring publication to make it the new centre.