BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.

doi:10.1200/JCO.2014.58.3922

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Article

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2015

Mistry Matthew, Zhukova Nataliya, Merico Daniele, Rakopoulos Patricia, Krishnatry Rahul, Shago Mary, Stavropoulos James, Alon Noa, Pole Jason D, Ray Peter N, Navickiene Vilma, Mangerel Joshua, Remke Marc, Buczkowicz Pawel, Ramaswamy Vijay, Guerreiro Stucklin Ana, Li Martin, Young Edwin J, Zhang Cindy, Castelo-Branco Pedro, Bakry Doua, Laughlin Suzanne, Shlien Adam, Chan Jennifer, Ligon Keith L, Rutka James T, Dirks Peter B, Taylor Michael D, Greenberg Mark, Malkin David, Huang Annie, Bouffet Eric, Hawkins Cynthia E, Tabori Uri

Abstract excerpt

PURPOSE: To uncover the genetic events leading to transformation of pediatric low-grade glioma (PLGG) to secondary high-grade glioma (sHGG). PATIENTS AND METHODS: We retrospectively identified patients with sHGG from a population-based cohort of 886 patients with PLGG with long clinical follow-up...

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Identifiers

PMID: 25667294
DOI: 10.1200/JCO.2014.58.3922
PMCID: PMC4356711

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25667294-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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