Article

Understanding the impact of feedback regulations on blood cell production and leukemia dynamics using model analysis and simulation of clinically relevant scenarios

2024-02-04

Abstract excerpt

Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML is the expansion of malignant cells in the bone marrow and the out-competition of healthy blood-forming (hematopoietic) cells. In the present study, we develop a nonlinear ordinary differential equation model to study the impact of feedback...

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Literature Corpus work: b6d5ee03-b506-56d7-9d52-86a7ca8118f6
DOI: 10.1016/j.apm.2024.01.048

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