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Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation

19 Dec 2012

Abstract excerpt

A very high number of different types of blood cells must be generated daily through a process called haematopoiesis in order to meet the physiological requirements of the organism. All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. Steady-state dynamics are governed by cell...

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PMID: 23256190
DOI: 10.1098/rsif.2012.0817

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