Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of cancer stem cell lineage involving feedback regulation.

PloS one - 1 Jan 2021

Batool Iqra, Bajcinca Naim

Abstract excerpt

Tumor emergence and progression is a complex phenomenon that assumes special molecular and cellular interactions. The hierarchical structuring and communication via feedback signaling of different cell types, which are categorized as the stem, progenitor, and differentiated cells in dependence of their maturity level, plays an important role. Under healthy conditions, these cells build a dynamical system that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Lineage
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Models, Biological

Share to Mutation

Share to Neoplasms

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34014979
DOI: 10.1371/journal.pone.0251481
PMCID: PMC8136751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of cancer stem cell lineage involving feedback regulation.PMID 34014979Read ↗

A mathematical model of cancer stem cell driven tumor initiation: implications of niche size and loss of homeostatic regulatory mechanisms.Semantic proximity Read ↗

Multispecies model of cell lineages and feedback control in solid tumorsSemantic proximity Read ↗

Determinants of stem cell enrichment in healthy tissues and tumors: implications for non-genetic drug resistanceSemantic proximity Read ↗

Evolutionary dynamics of feedback escape and the development of stem-cell-driven cancers.Semantic proximity Read ↗

Cancer stem cells and tumor dormancy.Semantic proximity Read ↗

Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny.Semantic proximity Read ↗

Modeling dynamics for oncogenesis encompassing mutations and genetic instability.Semantic proximity Read ↗

Evolution and phenotypic selection of cancer stem cells.Semantic proximity Read ↗

Mathematical model for the cancer stem cell hypothesis.Semantic proximity Read ↗

Non-stem cancer cell kinetics modulate solid tumor progressionSemantic proximity Read ↗

A mathematical model with aberrant growth correction in tissue homeostasis and tumor cell growth.Semantic proximity Read ↗

Understanding the impact of feedback regulations on blood cell production and leukemia dynamics using model analysis and simulation of clinically relevant scenariosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.