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Dynamics of Leukemia Stem-like Cell Extinction in Acute Promyelocytic Leukemia

1 Aug 2014

Abstract excerpt

Many tumors are believed to be maintained by a small number of cancer stem-like cells, where cure is thought to require eradication of this cell population. In this study, we investigated the dynamics of acute promyelocytic leukemia (APL) before and during therapy with regard to disease initiation, progression, and therapeutic response. This investigation used a mathematical model of hematopoiesis and a dataset...

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PMID: 25082816
DOI: 10.1158/0008-5472.can-14-1210

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