Article

Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

2022-10-14

Abstract excerpt

Chronic myeloid leukemia (CML) is a blood cancer characterized by dysregulated production of maturing myeloid cells driven by the product of the Philadelphia chromosome, the BCR-ABL1 tyrosine kinase. Tyrosine kinase inhibitors (TKI) have proved effective in treating CML but there is still a cohort of patients who do not respond to TKI therapy even in the absence of mutations in the BCR-ABL1 kinase domain that medi...

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Literature Corpus work: 347bc8d7-1018-5b84-952c-d114631d8295
DOI: 10.1101/2022.10.11.511822

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