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Article

Feedback mechanisms control coexistence in a stem cell model of acute myeloid leukaemia

29 Apr 2016

Abstract excerpt

Haematopoietic stem cell dynamics regulate healthy blood cell production and are disrupted during leukaemia. Competition models of cellular species help to elucidate stem cell dynamics in the bone marrow microenvironment (or niche), and to determine how these dynamics impact leukaemia progression. Here we develop two models that target acute myeloid leukaemia with particular focus on the mechanisms that control...

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PMID: 27130539
DOI: 10.1016/j.jtbi.2016.04.002

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