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Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer

3 Jun 2022

Abstract excerpt

Human papillomavirus (HPV)-positive head and neck cancers, predominantly oropharyngeal squamous cell carcinoma (OPSCC), exhibit epidemiologic, clinical, and molecular characteristics distinct from those OPSCCs lacking HPV. We applied a combination of whole-genome sequencing and optical genome mapping to interrogate the genome structure of HPV-positive OPSCCs. We found that the virus had integrated in the host...

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PMID: 35657601
DOI: 10.1158/1541-7786.mcr-21-0831

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