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Causes and Consequences of HPV Integration in Head and Neck Squamous Cell Carcinomas: State of the Art

13 Aug 2021

Abstract excerpt

A constantly increasing incidence in high-risk Human Papillomaviruses (HPV)s driven head and neck squamous cell carcinomas (HNSCC)s, especially of oropharyngeal origin, is being observed. During persistent infections, viral DNA integration into the host genome may occur. Studies are examining if the physical status of the virus (episomal vs. integration) affects carcinogenesis and eventually has further-reaching...

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PMID: 34439243
DOI: 10.3390/cancers13164089

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