Article

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

2024-04-03

Abstract excerpt

DNA methylation, as exemplified by cytosine-C5 methylation in mammals and adenine-N6 methylation in bacteria, is a crucial epigenetic mechanism driving numerous vital biological processes. Developing non-nucleoside inhibitors to cause DNA hypomethylation is a high priority, in order to treat a variety of significant medical conditions without the toxicities associated with existing cytidine-based hypomethylating a...

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Literature Corpus work: b6947497-73e2-5b26-90d7-a0a1409083b2
DOI: 10.1101/2024.04.03.587980

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