Article

Current Chemicals Used for Probing DNA Conformational Changes and Detection of Unknown Mutations.

2004-12-01

Abstract excerpt

Detection of unknown mutations is a key for success in diagnosis, treatment and therapy of many genetic diseases. Use of chemicals has been practiced for many years to probe the structural changes of DNA induced by a single base mismatch. This paper will review the current chemicals, such as carbodiimides, alkyl halides, aldehydes, oxidants, oxyamines, intercalators and groove binders, which have established the f...

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Literature Corpus work: f8209822-8e5e-5209-a352-286e7c8f47fc
DOI: 10.2174/1570160043377312

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