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Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

6 May 2019

Abstract excerpt

Abstract Background DNA methyltransferases (DNMTs) are epigenetic enzymes involved in embryonic development, cell differentiation, epithelial to mesenchymal transition, and control of gene expression, whose overexpression or enhanced catalytic activity has been widely reported in cancer initiation and progression. To date, two DNMT inhibitors (DNMTi), 5-azacytidine (5-AZA) and 5-aza-2′-deoxycytidine (DAC), are...

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PMID: 31060628
DOI: 10.1186/s13148-019-0663-8

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